Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

B24658 Ethyl p-toluenesulfonate, 98%

CAS Number
80-40-0
Synonyms
Ethyl tosylate
p-Toluenesulfonic acid ethyl ester

Stock No. Size Price ($) Quantity Availability
B24658-18 50g 20.60
B24658-30 250g 66.00
B24658-0B 1000g 240.00
Add to Cart Bulk/Specialty Print Quote View Item

Ethyl p-toluenesulfonate, 98%

MDL
MFCD00009100
EINECS
201-276-7

Chemical Properties

Formula
C9H12O3S
Formula Weight
200.26
Melting point
29-34°
Boiling Point
221°
Flash Point
157°(314°F)
Density
1.170
Refractive Index
1.5110
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Insoluble in water.

Applications

Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.

Notes

Moisture sensitive. Store away from oxidizing agent.

Literature References

Roberto Alzaga; Robert W Ryan; Karen Taylor-Worth; Andrew M Lipczynski; Roman Szucs; Pat Sandra. A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization-headspace-gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 45 (3), 472-479.

Ivelisse Colón; Stephen M Richoll. Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS. Journal of Pharmaceutical and Biomedical Analysis. 2005, 39 (3-4), 477-485.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335-H341-H351

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing genetic defects. Suspected of causing cancer.

Precautionary Statements: P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3858
Beilstein
611213
Harmonized Tariff Code
2904.10
TSCA
Yes
RTECS
XT6825000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware