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80-40-0 - Ethyl p-toluenesulfonate, 98% - Ethyl tosylate - p-Toluenesulfonic acid ethyl ester - B24658 - Alfa Aesar

B24658 Ethyl p-toluenesulfonate, 98%

CAS Number
80-40-0
Synonyms
Ethyl tosylate
p-Toluenesulfonic acid ethyl ester

Size Price ($) Quantity Availability
50g 19.30
250g 64.80
1000g 230.00
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Ethyl p-toluenesulfonate, 98%

MDL
MFCD00009100
EINECS
201-276-7

Chemical Properties

Formula
C9H12O3S
Formula Weight
200.26
Melting point
29-34°
Boiling Point
221°
Flash Point
157°(314°F)
Density
1.170
Refractive Index
1.5110
Sensitivity
Moisture Sensitive
Solubility
Insoluble in water.

Applications

Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.

Notes

Moisture sensitive. Store away from oxidizing agent.

Literature References

Roberto Alzaga; Robert W Ryan; Karen Taylor-Worth; Andrew M Lipczynski; Roman Szucs; Pat Sandra. A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization-headspace-gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 45 (3), 472-479.

Ivelisse Colón; Stephen M Richoll. Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS. Journal of Pharmaceutical and Biomedical Analysis. 2005, 39 (3-4), 477-485.

GHS Hazard and Precautionary Statements

Hazard Statements: H341-H302-H315-H319-H335

Suspected of causing genetic defects. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P301+P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3858
Beilstein
611213
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2904.10
TSCA
Yes
RTECS
XT6825000

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