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57381-39-2 - 2-Bromo-5-fluorobenzonitrile, 98+% - B24989 - Alfa Aesar

B24989 2-Bromo-5-fluorobenzonitrile, 98+%

CAS Number
57381-39-2
Synonyms

Size Price ($) Quantity Availability
5g 42.30
25g 185.40
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2-Bromo-5-fluorobenzonitrile, 98+%

MDL
MFCD00142875
EINECS
260-711-9

Chemical Properties

Formula
C7H3BrFN
Formula Weight
200.01
Melting point
88-92°
Solubility
Soluble in methanol.

Applications

2-Bromo-5-fluorobenzonitrile is used in the synthesis of pyrimidine functional compounds acting as GABAAα2/α3 binding site agonists used in the treatment of anxiety disorders.

Notes

Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

Michael G. N. Russell; Robert W. Carling; Leslie J. Street; David J. Hallett; Simon Goodacre; Elena Mezzogori; Michael Reader; Susan M. Cook; Frances A. Bromidge; Robert Newman; Alison J. Smith; Keith A. Wafford; George R. Marshall; David S. Reynolds; Rebecca Dias; Pushpindar Ferris; Jo Stanley; Rachael Lincoln; Spencer J. Tye; Wayne F. A. Sheppard; Bindi Sohal; Andrew Pike; Maria Dominguez; John R. Atack and José L. Castro. Discovery of Imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 Subtype Selective Agonists for the Treatment of Anxiety. J. Med. Chem.2006, 49, (4), 1235-1238.

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H302-H312-H315-H319-H335

Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P311-P362-P301+P312-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
8678330
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
No

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