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Creatine monohydrate is involved in rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). It may be used as a supplement to study its uptake mechanism and metabolism of action. It is used in the treatment of neuromuscular diseases.
Clare E Turner; Winston D Byblow; Nicholas Gant. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. Journal of Neuroscience.2015, 35, (4), 1773-1780.
Mark D Schuenke; Naomi E Brooks; Robert S Hikida. Interactions of aging, overload, and creatine supplementation in rat plantaris muscle. Journal of Aging Research.2011, 2011, 393416.