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B25057 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%

CAS Number
1892-57-5
Synonyms
N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide

Stock No. Size Price ($) Quantity Availability
B25057-06 5g 83.60
B25057-14 25g 288.00
B25057-22 100g 1057.00
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%

MDL
MFCD00044916
EINECS
217-579-2

Chemical Properties

Formula
C8H17N3
Formula Weight
155.24
Boiling Point
66-68°/1mm
Flash Point
>110°(230°F)
Density
0.885
Refractive Index
1.4610
Storage & Sensitivity
Store at -20°C. Moisture Sensitive. Air Sensitive. Store under Argon.
Solubility
Soluble in water.

Applications

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

Notes

Air sensitive. Incompatible with strong acids and strong oxidizing agents.

Literature References

Free base form of 'Water-soluble' carbodiimide. For applications see following entry. In the presence of CuCl2, (E)- or (Z)-2-substituted 3-hydroxy-3-phenylpropionate esters can be dehydrated stereoselectively to the corresponding (E) or (Z)-cinnamates: Tetrahedron Lett., 40, 5019 (1999).

Li, J.; Yue, L.; Li, C.; Pan, Y.; Yang, L. Enantioselectivity and catalysis improvements of Pseudomonas cepacia lipase with Tyr and Asp modification. Catal. Sci. Technol. 2015, 5, 2681-2687.

Lopez, R. J.; Babanova, S.; Artyushkova, K.; Atanassov, P. Surface modifications for enhanced enzyme immobilization and improved electron transfer of PQQ-dependent glucose dehydrogenase anodes. Bioelectrochemistry 2015, 105, 78-87.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
507429
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2925.19
TSCA
Yes

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