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B25096 Nalidixic acid, 99%

CAS Number
389-08-2
Synonyms
1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Stock No. Size Price ($) Quantity Availability
B25096-06 5g 21.70
B25096-14 25g 76.10
B25096-22 100g 264.00
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Nalidixic acid, 99%

MDL
MFCD00006884
EINECS
206-864-7

Chemical Properties

Formula
C12H12N2O3
Formula Weight
232.24
Melting point
228-230°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in diethyl ether, acetone, methylene chloride, chloroform and methanol. Insoluble in water.

Applications

Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.

Notes

Light sensitive and air sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

Chintagari, S.; Hung, Y. C.; Hamanaka, D. Resistance of various STEC strains and serogroups to UV radiation and effect of nalidixic acid adaptation. Food Control 2015, 50, 313-319.

Dwivedi, G. R.; Maurya, A.; Yadav, D. K.; Khan, F.; Darokar, M. P.; Srivastava, S. K. Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistant Escherichia coli. Chem. Biol. Drug Des. 2015, 86 (3), 272-283.

GHS Hazard and Precautionary Statements

Hazard Statements: H317-H334-H336-H341

May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause drowsiness or dizziness. Suspected of causing genetic defects.

Precautionary Statements: P261-P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6359
Beilstein
750515
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
QN2885000

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