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Glyoxylic acid is used in Hopkins Cole reaction, which is used in the detection of tryptophan in proteins. It reacts with phenol to get 4-hydroxymandelic acid, which on further reaction with ammonia gives hydroxyphenylglycine, as a precursor to the drug amoxicillin. It is also used as a starting material for the preparation of 4-hydroxyphenylacetic acid, which is used to get atenolol. It is involved in the production of agrochemicals, aromas, cosmetic ingredient and pharmaceutical intermediate. It is also used in water purification and in the preservation of food. Further, it is employed as precursor in the synthesis of iron chelates. In addition to this, it serves as an intermediate of varnish material and dyes.
For use in aqueous hetero Diels-Alder reactions, see: Tetrahedron, 50, 10265 (1994).
Reagent for the facile deprotection of oximes in aqueous medium: Tetrahedron Lett., 45, 3161 (2004).
Qin, W.; Guo, R. Metallization of polyester fabric by autocatalytic copper plating process using glyoxylic acid as a reducing agent. Fiber Polym. 2015, 16 (8), 1671-1675.
Uslu, H.; Datta, D.; Kumar, S. Investigations on the Reactive Extraction of Glyoxylic Acid by Amberlite-LA2 Dissolved in Alcoholic Diluents. Sep. Sci. Technol. 2015, 50 (17), 2658-2667.
Hazard Statements: H290-H314-H317-H318
May be corrosive to metals. Causes severe skin burns and eye damage. May cause an allergic skin reaction. Causes serious eye damage.
Precautionary Statements: P234-P260-P264b-P272-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P333+P313-P363-P501c
Keep only in original container. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant