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1015-89-0 - 6(5H)-Phenanthridinone, 96% - B25187 - Alfa Aesar

B25187 6(5H)-Phenanthridinone, 96%

CAS Number
1015-89-0
Synonyms

Size Price ($) Quantity Availability
1g 38.60
5g 140.00
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6(5H)-Phenanthridinone, 96%

MDL
MFCD00004988
EINECS
213-804-3

Chemical Properties

Formula
C13H9NO
Formula Weight
195.22
Melting point
288-294°
Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.

Applications

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Notes

Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Literature References

Guoyong Song; Dan Chen; Cheng-Ling Pan; Robert H Crabtree; Xingwei Li. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: synthesis of polycyclic amides. Journal of Organic Chemistry.2010, 75, (21), 7487-7490.

D Weltin; J Marchal; P Dufour; E Potworowski; D Oth; P Bischoff. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncology Research.1994, 6, (9), 399-403.

Other References

Beilstein
140641
Harmonized Tariff Code
2933.79
TSCA
No
RTECS
SG0370000

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