B25187 6(5H)-Phenanthridinone, 96%
SDS
| Stock No. | Size | Price ($) | Quantity | Availability |
|---|---|---|---|---|
| B25187-03 | 1g | 36.40 |
|
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| B25187-06 | 5g | 131.00 |
|
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6(5H)-Phenanthridinone, 96%
Chemical Properties
Applications
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Notes
Literature References
Guoyong Song; Dan Chen; Cheng-Ling Pan; Robert H Crabtree; Xingwei Li. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: synthesis of polycyclic amides. Journal of Organic Chemistry.2010, 75, (21), 7487-7490.
D Weltin; J Marchal; P Dufour; E Potworowski; D Oth; P Bischoff. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncology Research.1994, 6, (9), 399-403.
