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65-86-1 - Orotic acid, anhydrous, 97% - 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid - Uracil-4-carboxylic acid - B25349 - Alfa Aesar

B25349 Orotic acid, anhydrous, 97%

CAS Number
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
Uracil-4-carboxylic acid

Size Price ($) Quantity Availability
100g 85.18
500g 232.78
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Orotic acid, anhydrous, 97%


Chemical Properties

Formula Weight
Melting point
Slightly soluble in water.


Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.


Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Eun-Jeong Jung; Sung-Won Kwon; Byung-Hwa Jung; Seon-Hee Oh; Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of Lipid Research. 2011, 52,(9), 1617-1625.


Xing Wang; Xiuwen Wang; Mengxin Yin; Zijun Xiao; Cuiqing Ma; Zhixin Lin; Peng George Wang; Ping Xu. Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process. Applied Microbiology and Biotechnology. 2007, 76,(2), 321-328.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P270-P305+P351+P338-P362-P301+P312-P321-P332+P313-P337+P313-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • A15398

    Hydroxylamine hydrochloride, 99%
  • L03521

    Cyclobutyl methyl ketone, 97%
  • 47019

    Palladium, 5% on activated carbon powder, Type A109047-5, standard, reduced, nominally 50% water wet

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