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146374-27-8 - (±)-2-Methyl-2-propanesulfinamide, 97% - (+/-)-tert-Butyl sulfinamide - B25385 - Alfa Aesar

B25385 (±)-2-Methyl-2-propanesulfinamide, 97%

CAS Number
146374-27-8
Synonyms
(+/-)-tert-Butyl sulfinamide

Size Price ($) Quantity Availability
1g 47.80
5g 169.00
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(±)-2-Methyl-2-propanesulfinamide, 97%

MDL
MFCD05861480

Chemical Properties

Formula
(CH3)3CS(O)NH2
Formula Weight
121.20
Melting point
97-101°
Solubility
Soluble in methanol.

Applications

(±)-2-Methyl-2-propanesulfinamide is used in the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne. It is also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

John J.Caldwell; Ian Collins. Rapid synthesis of 4-benzyl-4-aminopiperidines by addition of Grignard reagents to N-(1-boc-piperidin-4-ylidene)-tert-butanesulfinyl imine. Synlett. 2006, (16), 2565-2568.

 

Joanne Hannam; Timothy Harrison; Felicity Heath; Andrew Madin; Kevin Merchant. Rapid and selective synthesis of substituted 1,2,5-thiadiazolidine 1,1-dioxides. Synlett. 2006, (6), 833-836.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2930.90
TSCA
No

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