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61-25-6 - Papaverine hydrochloride, 99% - 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride - B25412 - Alfa Aesar

B25412 Papaverine hydrochloride, 99%

CAS Number
61-25-6
Synonyms
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Size Price ($) Quantity Availability
5g 31.30
25g 98.60
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Papaverine hydrochloride, 99%

MDL
MFCD00012745
EINECS
200-502-1

Chemical Properties

Formula
C20H21NO4•HCl
Formula Weight
375.85
Melting point
ca 220° dec.
Sensitivity
Light Sensitive
Solubility
Soluble in water (50 mg/ml), DMSO, methanol, 100% ethanol and chloroform.

Applications

Papaverine hydrochloride is used as a smooth muscle relaxant, with noted treatment for impotence. It can also act as a cerebral vasodilator through the possible inhibition of PDE (phosphodiesterases) and/or calcium channel actions.

Notes

Light sensitive. Incompatible with oxidizing agents.

Literature References

H.W.Jayne; P.Scheinberg; M.Rich; M.S.Belle; Ione Blackburn. The effect of intravenous papaverine hydrochloride on the cerebral circulation. J Clin Invest. 1952, 31,(1), 111-114.

 

John S.Meyer, MD; Fumio Gotoh, MD; John Gilroy, MD; Nasaharu Nara, MD. Improvement in brain oxygenation and clinical improvement in patients with strokes treated with papaverine hydrochloride. JAMA. 1965, 194,(9), 957-961.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7019
Harmonized Tariff Code
2933.49
TSCA
Yes
RTECS
NW8575000

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