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5-(Trifluoromethoxy)isatin is used as a reactant for preparation of oxindole derivatives as TAk1 kinase inhibitors and of isatin thiosemicarbazones via condensation with thiosemicarbazones as herpes simplex virus (HSV) inhibitors. It is also used as a reactant for synthesis of 3-substituted 2-indolinone RET kinase inhibitors and for preparation of indolone acetamides as antiseizure agents.
Anne Frycia; Jean-Philippe Starck; Sophie Jadot; Benedicte Lallemand; Karine Leclercq; Patrick Lo Brutto; Alain Matagne; Valerie Verbois; Joel Mercier; Benoit Kenda. Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression. Chemmedchem. 2010, 5,(2), 200-205.
Jeffrey W.Lockman; Matthew D.Reeder; Rosann Robinson; Patricia A.Ormonde; Daniel M.Cimbora; Brandi L.Williams; J.Adam Willardsen. Oxindole derivatives as inhibitors of TAK1 kinase. Bioorganic & Medicinal Chemistry Letters. 2011, 21,(6), 1724-1727.