Dibenzyl N,N-diethylphosphoramidite may be used as phosphitylating reagent in the synthesis of glycosyl phosphites and phosphates, in the preparation of 6-dibenzylphosphate-1,3,5-tri-O-PMB-myo-inositol, for phosphorylating the alcohols.
Mui Mui Sim; Hirosato Kondo; Chi Huey Wong. Synthesis of dibenzyl glycosyl phosphites using dibenzyl N, N-diethylphosphoramidite as phosphitylating reagent: an effective route to glycosyl phosphates, nucleotides, and glycosides. J. Am. Chem. Soc. 1993, 115 (6), 2260-2267.
Peter A Jordan; Katherine J Kayser-Bricker; Scott J Miller. Asymmetric phosphorylation through catalytic P(III) phosphoramidite transfer: enantioselective synthesis of D-myo-inositol-6-phosphate. PNAS. 2010, 107 (48), 20620-20624.
Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron, 47, 2643 (1991); J. Org. Chem., 59, 7182 (1994). This sequence provides a convenient route to glycosyl phosphates via the glycosyl phosphites: J. Am. Chem. Soc. 115, 2260 (1993).
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280a-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.