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B25713 6-Chloro-7-deazapurine, 98%

CAS Number
3680-69-1
Synonyms
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Stock No. Size Price ($) Quantity Availability
B25713-03 1g 209.00
B25713-06 5g 819.00
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6-Chloro-7-deazapurine, 98%

MDL
MFCD01686865

Chemical Properties

Formula
C6H4ClN3
Formula Weight
153.52
Melting point
190-192°
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in DMSO, ethyl acetate and methanol.

Applications

6-Chloro-7-deazapurine is used for making tofacitinib.

Notes

Store in cool, dry place in a well sealed container. Store away from oxidizing agents.

Literature References

Helmut Rosemeyer and Frank Seela. Stereoselective synthesis of pyrrolo[2,3-d]pyrimidine α- and β-D-ribonucleosides from anomerically pure D-ribofuranosyl chlorides: Solid-Liquid Phase-Transfer Glycosylation and 15N-NMR Spectra. Helvetica Chimica Acta. 1988, 71 (6), 1573-1585.

Balakumar Arumugham; Hyo-Joong Kim; Mark N. Prichard; Earl R. Kern; Chung K. Chu. Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus). Bioorganic & Medicinal Chemistry Letters. 2006, 16 (2), 285-287.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.59
TSCA
No

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