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H25750 2,2-Difluoroacetophenone, 95%

CAS Number

Stock No. Size Price ($) Quantity Availability
H25750-MD 250mg 59.00
H25750-03 1g 172.00
H25750-06 5g 621.00
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2,2-Difluoroacetophenone, 95%


Chemical Properties

Formula Weight
Melting point
Boiling Point
Refractive Index
Storage & Sensitivity
Ambient temperatures.
Immiscible with water.


2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.


Incompatible with strong oxidizing agents and strong acids.

Literature References

Kitamura, T.; Muta, K.; Muta, K. Hypervalent Iodine-Promoted alpha-Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex. J. Org. Chem. 2014, 79 (12), 5842-5846.

Dudzik, A.; Snoch, W.; Borowiecki, P.; Opalinska-Piskorz, J.; Witko, M.; Heider, J.; Szaleniec, M. Asymmetric reduction of ketones and beta-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum. Appl. Microbiol. Biotechnol. 2014, 99 (12), 5055-5069.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A11215

    Ethyl difluoroacetate, 98%
  • B24710

    DL-Penicillamine, 97+%
  • H50590

  • 41841

    Toluene, anhydrous, 99.8%, packaged under Argon in resealable ChemSeal™ bottles
  • H54229

    4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline, 97%

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