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395-01-7 - 2,2-Difluoroacetophenone, 95% - H25750 - Alfa Aesar

H25750 2,2-Difluoroacetophenone, 95%

CAS Number
395-01-7
Synonyms

Size Price ($) Quantity Availability
250mg 58.50
1g 171.00
5g 620.00
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2,2-Difluoroacetophenone, 95%

MDL
MFCD06246879

Chemical Properties

Formula
C8H6F2O
Formula Weight
156.13
Melting point
48-50°
Boiling Point
53-54°/12mm
Refractive Index
1.4955
Solubility
Immiscible with water.

Applications

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Notes

Incompatible with strong oxidizing agents and strong acids.

Literature References

Kitamura, T.; Muta, K.; Muta, K. Hypervalent Iodine-Promoted alpha-Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex. J. Org. Chem. 2014, 79 (12), 5842-5846.

Dudzik, A.; Snoch, W.; Borowiecki, P.; Opalinska-Piskorz, J.; Witko, M.; Heider, J.; Szaleniec, M. Asymmetric reduction of ketones and beta-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum. Appl. Microbiol. Biotechnol. 2014, 99 (12), 5055-5069.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Harmonized Tariff Code
2914.79
TSCA
No

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