It is used as a reactant for asymmetric hydrogenation with iridium catalysts, chemo selective reaction with deprotonated 2-hydoxy-3,3,N-trimethylbutanamide. It is also used as a reactant for synthesis of phosphine- containing amino acids and peptide-based catalyst ligands, nonracemic phosphine-containing amino acids for palladium- catalyzed asymmetric allylic substitution reactions.
Anton Agarkov; Scott Greenfield; Dejian Xie; Robert Pawlick; Gale Starkey; Scott R Gilbertson. Synthesis of phosphine containing amino acids: utilization of peptide synthesis in ligand design. Biopolymers. 2006, 84 (1), 48-73.
Scott J Greenfield; Anton Agarkov; Scott R Gilbertson. High asymmetric induction with beta-turn-derived palladium phosphine complexes. Organic Letters. 2003, 5 (17), 3069-3072.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.