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(1S,2R)-cis-4-Cyclohexene-1,2-dicarboxylic acid 1-monomethyl ester is used in organic synthesis as a starting material and intermediate.
Goswami, A.; Kissick, T. P. Enzymatic Desymmetrization of Dimethyl Cylcohex-4-ene-cis-1,2-dicarboxylate to (1S,2R)-2-(Methoxycarbonyl)cyclohex-4-ene-1-carboxylic Acid. Org. Process Res. Dev. 2009, 13 (3), 483-488.
Solano, D. M.; Hoyos, P.; Hernáiz, M. J.; Alcántara, A. R.; Sánchez-Montero, J. M. Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs. Bioresour. Technol. 2012, 115, 196-207.
Su?ss, P.; Illner, S.; von Langermann, J.; Borchert, S.; Bornscheuer, U. T.; Wardenga, R.; Kragl, U. Scale-Up of a Recombinant Pig Liver Esterase-Catalyzed Desymmetrization of Dimethyl Cyclohex-4-ene-cis-1,2-dicarboxylate. Org. Process Res. Dev. 2014, 18 (7), 897-903.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant