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148893-10-1 - O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99% - HATU - 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 1-oxide hexafluorophosphate - H26082 - Alfa Aesar

H26082 O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%

CAS Number
148893-10-1
Synonyms
HATU
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 1-oxide hexafluorophosphate

Size Price ($) Quantity Availability
1g 29.60
5g 53.00
25g 139.00
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O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%

MDL
MFCD00274639

Chemical Properties

Formula
C10H15F6N6OP
Formula Weight
380.23
Melting point
ca 185° dec.
Solubility
Soluble in acetonitrile. Insoluble in water.

Applications

O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate is a coupling reagent and used as an additive in peptide synthesis., It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.

Notes

Moisture sensitive. Incompatible with oxidizing agents and highly acidic or alkaline materials.

Literature References

Yoshida, M.; Sasahara, K. I.; Doi, T. Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support. Tetrahedron 2015, 71 (40), 7647-7653.

Xie, Y.; Yu, C.; Li, T.; Tu, S.; Yao, C. An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+ 2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones. Chem. Eur. J. 2015, 21 (14), 5355-5359.

GHS Hazard and Precautionary Statements

Hazard Statements: H228-H303-H315-H319-H335

Flammable solid. May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
4.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
XZ5633000

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