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O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate is a coupling reagent and used as an additive in peptide synthesis., It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Yoshida, M.; Sasahara, K. I.; Doi, T. Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support. Tetrahedron 2015, 71 (40), 7647-7653.
Xie, Y.; Yu, C.; Li, T.; Tu, S.; Yao, C. An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+ 2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones. Chem. Eur. J. 2015, 21 (14), 5355-5359.
Hazard Statements: H228-H303-H315-H319-H335
Flammable solid. May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.