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H26195 3-Chloro-5-fluorophenol, 98%

CAS Number
202982-70-5
Synonyms

Stock No. Size Price ($) Quantity Availability
H26195-03 1g 77.70
H26195-06 5g 229.00
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3-Chloro-5-fluorophenol, 98%

MDL
MFCD00042212
EINECS
None

Chemical Properties

Formula
C6H4ClFO
Formula Weight
146.55
Refractive Index
1.537
Storage & Sensitivity
Ambient temperatures.
Solubility
Immiscible with water.

Applications

3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Notes

Incompatible with strong oxidizing agents.

Literature References

Huang, H.; Ji, H.; Li, H.; Jing, Q.; Labby, K. J.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations. J. Am. Chem. Soc. 2012, 134 (28), 11559-11572.

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312-H314-H335

Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2908.19
TSCA
No

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