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202982-70-5 - 3-Chloro-5-fluorophenol, 98% - H26195 - Alfa Aesar

H26195 3-Chloro-5-fluorophenol, 98%

CAS Number
202982-70-5
Synonyms

Size Price ($) Quantity Availability
1g 83.00
5g 246.00
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3-Chloro-5-fluorophenol, 98%

MDL
MFCD00042212
EINECS
None

Chemical Properties

Formula
C6H4ClFO
Formula Weight
146.55
Refractive Index
1.537
Solubility
Immiscible with water.

Applications

3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Notes

Incompatible with strong oxidizing agents.

Literature References

Huang, H.; Ji, H.; Li, H.; Jing, Q.; Labby, K. J.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations. J. Am. Chem. Soc. 2012, 134 (28), 11559-11572.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H302-H312-H411-H401

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Harmful in contact with skin. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Precautionary Statements: P273-P280-P303+P361+P353-P305+P351+P338-P310

Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2908.19
TSCA
No

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