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548-04-9 - Hypericin, 98% - 4,4',5,5',7,7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone - Hypericum red - H26425 - Alfa Aesar

H26425 Hypericin, 98%

CAS Number
548-04-9
Synonyms
4,4',5,5',7,7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone
Hypericum red

Size Price ($) Quantity Availability
25mg 312.00
100mg 786.00
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Hypericin, 98%

MDL
MFCD00016683
EINECS
208-941-0

Chemical Properties

Formula
C30H16O8
Formula Weight
504.44
Melting point
ca 320° dec.
Sensitivity
Light Sensitive
Solubility
Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.

Applications

Inhibitor of protein kinase C; induces photosynthesized apoptosisHypercin acts as an antibiotic and antiviral. It is involved in the inhibition of enzyme dopamine beta-hydroxylase action. It also exhibits an anti-HIV and anticancer drug. Further, it is useful in photodynamic therapy. In addition to this, it serves as an inhibitor of protein kinase C which induces photosynthesized apoptosis.

Notes

Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Inhibitor of protein kinase C: Biochem Biophys. Res. Commun., 165, 1207 (1989); Photochem. Photobiol., 82, 720 (2006). Antiviral and antitumour photosensitizer: Photochem. Photobiol., 54, 95 (1991); Curr. Drug Targets, 3, 55 (2002).

Kusari, S.; Sezgin, S.; Nigutova, K.; Cellarova, E.; Spiteller, M. Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging. Anal. Bioanal. Chem. 2015, 407 (16), 4779-4791.

Vogler, A. Fluorescence spectra of complexes of hypericin with s2 metal cations. Inorg. Chem. Commun. 2015, 54, 61-62.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Precautionary Statements: P261-P280-P264-P270-P301+P312-P363-P321-P333+P313-P302+P352-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4863
Beilstein
1917913
Harmonized Tariff Code
2914.69
TSCA
No
RTECS
SF8472000

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