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H26473 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

CAS Number
30827-99-7
Synonyms
AEBSF

Stock No. Size Price ($) Quantity Availability
H26473-MD 250mg 204.00
H26473-03 1g 614.00
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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

MDL
MFCD00132962

Chemical Properties

Formula
C8H10FNO2S•HCl
Formula Weight
239.69
Melting point
ca 184° dec.
Storage & Sensitivity
Store at -20°C. Moisture Sensitive.
Solubility
Soluble in water 50 mg/mL or 100% ethanol.

Applications

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Notes

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Literature References

Lawson, W.B., et al,; Folia Haematol. Int. Mag. Klin. Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. Morphol. Blutforsch. 1982, 109(52)

M Citron,; T.S Diehl,; A Capell,; C Haass,; D.B Teplow,; D.J Selkoe. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF. Journal name. 1996, 17 (1),171-179.

Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H500

Causes severe skin burns and eye damage. May form combustible dust concentrations in air

Precautionary Statements: P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
7604627
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2922.29
TSCA
No

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