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30827-99-7 - 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97% - AEBSF - H26473 - Alfa Aesar

H26473 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

CAS Number
30827-99-7
Synonyms
AEBSF

Size Price ($) Quantity Availability
250mg 198.00
1g 529.60
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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

MDL
MFCD00132962

Chemical Properties

Formula
C8H10FNO2S•HCl
Formula Weight
239.69
Melting point
ca 184° dec.
Sensitivity
Moisture Sensitive
Solubility
Soluble in water 50 mg/mL or 100% ethanol.

Applications

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Notes

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Literature References

Lawson, W.B., et al,; Folia Haematol. Int. Mag. Klin. Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. Morphol. Blutforsch. 1982, 109(52)

M Citron,; T.S Diehl,; A Capell,; C Haass,; D.B Teplow,; D.J Selkoe. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF. Journal name. 1996, 17 (1),171-179.

Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
7604627
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2922.29
TSCA
No

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