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H26629 N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-Hydroxysuccinimide

CAS Number
74124-79-1
Synonyms
Su2O

Stock No. Size Price ($) Quantity Availability
H26629-03 1g 31.00
H26629-06 5g 90.10
H26629-14 25g 303.00
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N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-Hydroxysuccinimide

MDL
MFCD00009767
EINECS
277-730-3

Chemical Properties

Formula
C9H8N2O7
Formula Weight
256.17
Melting point
190° dec.
Storage & Sensitivity
Keep Cold. Hygroscopic. Store under Nitrogen.
Solubility
Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.

Applications

N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

Notes

Moisture sensitive. Store in a cool place. Incompatible with strong acids and oxidizing agents.

Literature References

Černoch, P.; Černochová, Z.; Kučka, J.; Hrubý, M.; Petrova, S.; Št?pánek, P. Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications. Appl. Radiat. Isot. 2015, 98, 7-12.

Nale, D. B.; Bhanage, B. M. Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction. Green Chem. 2015, 17 (4), 2480-2486.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1499137
Harmonized Tariff Code
2925.19
TSCA
No

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