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As pharmaceuticals, they find applications in antibiotics, as sedatives, and for cancer treatment. Used frequently in organic synthesis. Find application as propellants.
Richard Fuchs,; Gene Parks. Substituted α,αα-Trifluoroacetophenones, α-Trifluoromethylbenzyl Alcohols, and α-Chloro-α-trifluoromethyltoluenes. J. Med. Chem. 1957, 22 (8),993-994.
Robert W. Sullivan,; Colin G. Bigam,; Paul E. Erdman,; Moorthy S. S. Palanki,; David W. Anderson,; Mark E. Goldman,; Lynn J. Ransone,; Mark J. Suto. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3,5-bis(trifluoromethyl)phenyl)- carboxamide:? A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry. J. Med. Chem.1998, 41(4),413-419.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P280-P305+P351+P338-P309-P310a
Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: