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The synthesis of this class of compounds relies on the lithiation of racemic 2,2'-dibromo-1,1'-binaphthyl with t-BuLi followed by addition of Ph 2 PCl.
Yasuhiro Uozumi,; Hirokazu Kyota,; Eiji Kishi,; Kenji Kitayama,; Tamio Hayashi. Homochiral 2,2?-bis(oxazolyl)-1,1?-binaphthyls as ligands for copper(I)-catalyzed asymmetric cyclopropanation. Tetrahedron: Asymmetry. 1996, 7 (6),1603-1606.
Št?pán Vyskočil,; Martin Smrčina,; Vladimír Hanuš,;? Miroslav Polášek,; Pavel Kočovský. Derivatives of 2-Amino-2-diphenylphosphino-1,1-binaphthyl (MAP) and Their Application in Asymmetric Palladium(0)-Catalyzed Allylic Substitution. J. Org. Chem. 1998 , 63 22,7738-7748.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.