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The synthesis of this class of compounds relies on the lithiation of racemic 2,2'-dibromo-1,1'-binaphthyl with t-BuLi followed by addition of Ph 2 PCl.
Yasuhiro Uozumi,; Hirokazu Kyota,; Eiji Kishi,; Kenji Kitayama,; Tamio Hayashi. Homochiral 2,2?-bis(oxazolyl)-1,1?-binaphthyls as ligands for copper(I)-catalyzed asymmetric cyclopropanation. Tetrahedron: Asymmetry. 1996, 7 (6),1603-1606.
Št?pán Vyskočil,; Martin Smrčina,; Vladimír Hanuš,;? Miroslav Polášek,; Pavel Kočovský. Derivatives of 2-Amino-2-diphenylphosphino-1,1-binaphthyl (MAP) and Their Application in Asymmetric Palladium(0)-Catalyzed Allylic Substitution. J. Org. Chem. 1998 , 63 22,7738-7748.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant