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618-27-9 - cis-4-Hydroxy-L-proline, 99% - (2S,4S)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid - H-cis-Hyp-OH - H27194 - Alfa Aesar

H27194 cis-4-Hydroxy-L-proline, 99%

CAS Number
618-27-9
Synonyms
(2S,4S)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
H-cis-Hyp-OH

Size Price ($) Quantity Availability
250mg 142.04
1g 472.91
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cis-4-Hydroxy-L-proline, 99%

MDL
MFCD00064319
EINECS
210-542-1

Chemical Properties

Formula
C5H9NO3
Formula Weight
131.13
Melting point
ca 250° dec.
Solubility
Soluble in water.

Applications

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Heather Dickens et. al. Anticancer drug cis-4-hydroxy-L-proline: Correlation of preclinical toxicology with clinical parameters of liver function. Molecular Medicine Reports. 2008, 1(4), 459-464 .

Roux A, Xu Y,; Heilier JF,; Olivier MF,; Ezan E,; Tabet JC,; Junot C. Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Analytical chemistry. 2012, 84 6429-6437.

Other References

Harmonized Tariff Code
2933.99
TSCA
Yes

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