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59-14-3 - 5-Bromo-2'-deoxyuridine, 99% - 5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil - 5-BrdU - H27260 - Alfa Aesar

H27260 5-Bromo-2'-deoxyuridine, 99%

CAS Number
59-14-3
Synonyms
5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil
5-BrdU

Size Price ($) Quantity Availability
250mg 31.60
1g 83.00
5g 264.00
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5-Bromo-2'-deoxyuridine, 99%

MDL
MFCD00006529
EINECS
200-415-9

Chemical Properties

Formula
C9H11BrN2O5
Formula Weight
307.10
Melting point
ca 190° dec.
Solubility
Soluble in water.

Applications

5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Chen Li,; Avrum I. Gotlieb. Transforming Growth Factor-β Regulates the Growth of Valve Interstitial Cellsin Vitro. The American Journal of Pathology. 2011, 179 (4), 1746-1755 .

Yu Gui et. al. Signaling mechanisms mediating uridine adenosine tetraphosphate-induced proliferation of human vascular smooth muscle cells. Journal of Cardiovascular Pharmacology. 2011 , 58(6), 654-662 .

Thymidine analog, preferentially incorporated into cellular DNA in place of thymidine, producing increased radiosensitivity of the cell: Int. J. Radiat. Oncol. Biol. Phys., 10, 1399 (1984); 21, 709 (1991). Mutagen used in genetic research: Mutat. Res., 258, 161 (1991). Reviews on use in diagnostics and research: Histochem. J., 27, 339, 923 (1995; 28, 531 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H341

Suspected of causing genetic defects.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1452
Beilstein
30395
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
YU7350000

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