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117924-33-1 - Di-tert-butyl N,N-diethylphosphoramidite, 94% - H27380 - Alfa Aesar

H27380 Di-tert-butyl N,N-diethylphosphoramidite, 94%

CAS Number
117924-33-1
Synonyms

Size Price ($) Quantity Availability
1g 63.70
5g 196.00
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Di-tert-butyl N,N-diethylphosphoramidite, 94%

MDL
MFCD00134307

Chemical Properties

Formula
[(CH3)3CO]2PN(CH2CH3)2
Formula Weight
249.33
Boiling Point
39-41°/0.3mm
Flash Point
78°(172°F)
Density
0.896
Refractive Index
1.434
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.

Applications

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Notes

Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Literature References

Perich. J. W, et al. Di-tert-butyl N,N-diethylphosphoramidite. A new phosphitylating agent for the efficient phosphorylation of alcohols.Synthesis.,1988,2142-144.

Roland Sauer, et al. Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists.J. Med. Chem.,2000,43(3), 440-448.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H227

Causes skin irritation. Causes serious eye irritation. Combustible liquid.

Precautionary Statements: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Harmonized Tariff Code
2931.90
TSCA
No

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