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H27380 Di-tert-butyl N,N-diethylphosphoramidite, 94%

CAS Number
117924-33-1
Synonyms

Stock No. Size Price ($) Quantity Availability
H27380-03 1g 67.60
H27380-06 5g 208.00
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Di-tert-butyl N,N-diethylphosphoramidite, 94%

MDL
MFCD00134307

Chemical Properties

Formula
[(CH3)3CO]2PN(CH2CH3)2
Formula Weight
249.33
Boiling Point
39-41°/0.3mm
Flash Point
78°(172°F)
Density
0.896
Refractive Index
1.434
Storage & Sensitivity
Keep Cold. Moisture Sensitive. May form a Precipitate.
Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.

Applications

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Notes

Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Literature References

Perich. J. W, et al. Di-tert-butyl N,N-diethylphosphoramidite. A new phosphitylating agent for the efficient phosphorylation of alcohols.Synthesis.,1988,2142-144.

Roland Sauer, et al. Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists.J. Med. Chem.,2000,43(3), 440-448.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319

Combustible liquid. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P210-P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2931.39
TSCA
No

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