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2257-69-4 - 1-Chlorophthalazin-4-one, 98% - H27515 - Alfa Aesar

H27515 1-Chlorophthalazin-4-one, 98%

CAS Number
2257-69-4
Synonyms

Size Price ($) Quantity Availability
1g 31.80
250mg 37.90
5g 86.94
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1-Chlorophthalazin-4-one, 98%

MDL
MFCD00102192

Chemical Properties

Formula
C8H5ClN2O
Formula Weight
180.59
Melting point
270-274°

Applications

1-Chlorophthalazin-4-one acts as an organic and pharmaceutical intermediate.

Notes

Incompatible with oxidizing agents and bases.

Literature References

Procopiou, P. A.; Browning, C.; Buckley, J. M.; Clark, K. L.; Fechner, L.; Gore, P. M.; Hancock, A. P.; Hodgson, S. T.; Holmes, D. S.; Kranz, M.; Looker, B. E.; Morriss, K. M. L.; Parton, D. L.; Russell, L. J.; Slack, R. J.; Sollis, S. L.; Vile, S.; Watts, C. J. The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis. J. Med. Chem. 2011, 54 (7), 2183-2195.

Larsson, E. A.; Jansson, A.; Ng, F. M.; Then, S. W.; Panicker, R.; Liu, B.; Sangthongpitag, K.; Pendharkar, V.; Tai, S. J.; Hill, J.; Dan, C.; Ho, S. Y.; Cheong, W. W.; Poulsen, A.; Blanchard, S.; Lin, G. R.; Alam, J.; Keller, T. H.; Nordlund, P. Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases. J. Med. Chem. 2013, 56 (11), 4497-4508.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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