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1-Chlorophthalazin-4-one acts as an organic and pharmaceutical intermediate.
Procopiou, P. A.; Browning, C.; Buckley, J. M.; Clark, K. L.; Fechner, L.; Gore, P. M.; Hancock, A. P.; Hodgson, S. T.; Holmes, D. S.; Kranz, M.; Looker, B. E.; Morriss, K. M. L.; Parton, D. L.; Russell, L. J.; Slack, R. J.; Sollis, S. L.; Vile, S.; Watts, C. J. The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis. J. Med. Chem. 2011, 54 (7), 2183-2195.
Larsson, E. A.; Jansson, A.; Ng, F. M.; Then, S. W.; Panicker, R.; Liu, B.; Sangthongpitag, K.; Pendharkar, V.; Tai, S. J.; Hill, J.; Dan, C.; Ho, S. Y.; Cheong, W. W.; Poulsen, A.; Blanchard, S.; Lin, G. R.; Alam, J.; Keller, T. H.; Nordlund, P. Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases. J. Med. Chem. 2013, 56 (11), 4497-4508.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant