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H27515 1-Chlorophthalazin-4-one, 98%

CAS Number
2257-69-4
Synonyms

Stock No. Size Price ($) Quantity Availability
H27515-MD 250mg 35.70
H27515-03 1g 83.70
H27515-06 5g 249.00
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1-Chlorophthalazin-4-one, 98%

MDL
MFCD00102192

Chemical Properties

Formula
C8H5ClN2O
Formula Weight
180.59
Melting point
270-274°
Storage & Sensitivity
Ambient temperatures.

Applications

1-Chlorophthalazin-4-one acts as an organic and pharmaceutical intermediate.

Notes

Incompatible with oxidizing agents and bases.

Literature References

Procopiou, P. A.; Browning, C.; Buckley, J. M.; Clark, K. L.; Fechner, L.; Gore, P. M.; Hancock, A. P.; Hodgson, S. T.; Holmes, D. S.; Kranz, M.; Looker, B. E.; Morriss, K. M. L.; Parton, D. L.; Russell, L. J.; Slack, R. J.; Sollis, S. L.; Vile, S.; Watts, C. J. The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis. J. Med. Chem. 2011, 54 (7), 2183-2195.

Larsson, E. A.; Jansson, A.; Ng, F. M.; Then, S. W.; Panicker, R.; Liu, B.; Sangthongpitag, K.; Pendharkar, V.; Tai, S. J.; Hill, J.; Dan, C.; Ho, S. Y.; Cheong, W. W.; Poulsen, A.; Blanchard, S.; Lin, G. R.; Alam, J.; Keller, T. H.; Nordlund, P. Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases. J. Med. Chem. 2013, 56 (11), 4497-4508.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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