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H27627 4-(Methoxycarbonyl)benzeneboronic acid, 97%

CAS Number
99768-12-4
Synonyms
4-(Methoxycarbonyl)phenylboronic acid
Methyl 4-boronobenzoate

Stock No. Size Price ($) Quantity Availability
H27627-03 1g 58.40
H27627-06 5g 175.00
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4-(Methoxycarbonyl)benzeneboronic acid, 97%

MDL
MFCD01632203

Chemical Properties

Formula
C8H9BO4
Formula Weight
179.97
Melting point
220-225°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in methanol.

Applications

It is a reagent used for tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence, copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, one-pot ipso-nitration of arylboronic acids, copper-catalyzed nitration and cyclocondensation followed by palladium-phosphine-catalyzed Suzuki-Miyaura coupling. It is employed as reagent in Reagent used in preparation of biaryls via nickel-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acid, chromenones and their bradykinin B1 antagonistic activity, Pt nanoparticles on Photoactive metal-organic frameworks resulting in efficient hydrogen evolution via synergistic photoexcitation and electron injection and salicylate-based thienylbenzoic acids as E. coli methionine aminopeptidase inhibitor.

Notes

Store in cool dry conditions. Incompatible with oxidizing agents. Ensure good ventilation.

Literature References

Mark D. Hylarides.; D. Scott Wilbur.; Stephen W. Hadley.; Alan R. Fritzberg. Synthesis and iodination of methyl 4-tri-n-butylstannylbenzoate, p-(methoxycarbonyl)phenylmercuric chloride and p-(methoxycarbonyl)phenylboronic acid. J. Organomet. Chem. 1989, 367 (3), 259-265 .

Hirokazu Tsukamoto.; Yoshinori Kondo. Palladium(II)-Catalyzed Annulation of Alkynes with ortho-Ester-Containing Phenylboronic Acids.Org. LettOrg. Lett. 2007, 9 (21),4227-4230 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2931.90
TSCA
No

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