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4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives.
Tran, L. D.; Roane, J.; Daugulis, O. Directed Amination of Non-Acidic Arene C[BOND]H Bonds by a Copper-Silver Catalytic System. Angew. Chem. Int. Ed. 2013, 52 (23), 6043-6046.
Woo, H. M.; Lee, Y. S.; Roh, E. J.; Seo, S. H.; Song, C. M.; Chung, H. J.; Pae, A. N.; Shin, K. J. Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers. Bioorg. Med. Chem. Lett. 2011, 21 (19), 5910-5915.
Hazard Statements: H227-H302-H311-H332-H315-H319-H335
Combustible liquid. Harmful if swallowed. Toxic in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338-P309-P310a
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor