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H27724 (R)-(+)-2-Methyl-2-propanesulfinamide, 98%

CAS Number
(R)-(+)-tert-Butyl sulfinamide

Stock No. Size Price ($) Quantity Availability
H27724-03 1g 66.10
H27724-06 5g 223.00
H27724-14 25g 762.00
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(R)-(+)-2-Methyl-2-propanesulfinamide, 98%


Chemical Properties

Formula Weight
Melting point
ca 100-105°
Storage & Sensitivity
Keep Cold.
Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.


(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.


Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place.

Literature References

Qian, X.; Tang, E.; Fan, J.; Zhu, K.; Zhu, J.; Shabaker, J.; Lo, E.; Malley, M.; Deshpande, R. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR alpha/gamma dual agonist. Tetrahedron 2015, 71 (50), 9408-9414.

Bender, A. M.; Griggs, N. W.; Anand, J. P.; Traynor, J. R.; Jutkiewicz, E. M.; Mosberg, H. I. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy mu Opioid Receptor/delta Opioid Receptor Ligands. ACS Chem. Neurosci. 2015, 6 (8), 1428-1435.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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