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196929-78-9 - (R)-(+)-2-Methyl-2-propanesulfinamide, 98% - (R)-(+)-tert-Butyl sulfinamide - H27724 - Alfa Aesar

H27724 (R)-(+)-2-Methyl-2-propanesulfinamide, 98%

CAS Number
196929-78-9
Synonyms
(R)-(+)-tert-Butyl sulfinamide

Size Price ($) Quantity Availability
1g 65.60
5g 222.00
25g 818.00
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(R)-(+)-2-Methyl-2-propanesulfinamide, 98%

MDL
MFCD05861479

Chemical Properties

Formula
C4H11NOS
Formula Weight
121.20
Melting point
ca 100-105°
Solubility
Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.

Applications

(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.

Notes

Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place.

Literature References

Qian, X.; Tang, E.; Fan, J.; Zhu, K.; Zhu, J.; Shabaker, J.; Lo, E.; Malley, M.; Deshpande, R. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR alpha/gamma dual agonist. Tetrahedron 2015, 71 (50), 9408-9414.

Bender, A. M.; Griggs, N. W.; Anand, J. P.; Traynor, J. R.; Jutkiewicz, E. M.; Mosberg, H. I. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy mu Opioid Receptor/delta Opioid Receptor Ligands. ACS Chem. Neurosci. 2015, 6 (8), 1428-1435.

Other References

Harmonized Tariff Code
2930.90
TSCA
No

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