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203866-18-6 - N-Boc-trans-4-fluoro-L-proline methyl ester, 97% - (2S,4R)-4-Fluoropyrrolidine-1,2-dicarboxylic acid 1-tert-butyl 2-methyl diester - H27747 - Alfa Aesar

H27747 N-Boc-trans-4-fluoro-L-proline methyl ester, 97%

CAS Number
203866-18-6
Synonyms
(2S,4R)-4-Fluoropyrrolidine-1,2-dicarboxylic acid 1-tert-butyl 2-methyl diester

Size Price ($) Quantity Availability
250mg 66.88
1g 250.20
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N-Boc-trans-4-fluoro-L-proline methyl ester, 97%

MDL
MFCD07367993

Chemical Properties

Formula
C11H18FNO4
Formula Weight
247.27
Melting point
36-39°
Solubility
Insoluble in water.

Applications

N-Boc-trans-4-fluoro-L-proline methyl ester is used to prepare (S)-2-[N-(N'-benzyl-(S)-4-fluoro-L-prolyl)amino]benzophenone by reacting with of 2-aminobenzophenone in the presence of potassium tert -butoxide.

Notes

Incompatible with strong oxidizing agents and strong bases.

Literature References

Tatum, N. J.; Yufit, D. S.; Cobb, S. L.: Coxon, C. R. Synthesis, Ni(II) Schiff base complexation and structural analysis of fluorinated analogs of the ligand (S)-2-[N-(N'-benzylprolyl)amino]benzophenone (BPB). J. Fluorine Chem. 2015, 13 (173), 77-83.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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