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24067-17-2 - 4-Nitrobenzeneboronic acid, 95% - 4-Nitrophenylboronic acid - H27767 - Alfa Aesar

H27767 4-Nitrobenzeneboronic acid, 95%

CAS Number
24067-17-2
Synonyms
4-Nitrophenylboronic acid

Size Price ($) Quantity Availability
1g 57.90
5g 188.00
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4-Nitrobenzeneboronic acid, 95%

MDL
MFCD00161360

Chemical Properties

Formula
C6H6BNO4
Formula Weight
166.93
Melting point
ca 285° dec.
Solubility
Slightly soluble in water.

Applications

It is reagent used forligand-free palladium-catalyzed Suzuki-Miyaura cross-couplings, ruthenium catalyzed direct arylation of benzylic sp3 carbons of acyclic amines, Diels-Alder or C-H activation reactions, regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulations, N-arylation of phenylurea using copper acetylacetonate catalyst, environmentally benign one-pot synthesis through a double arylation process, copper-mediated cyanation, copper-catalyzed arylations regioselective glycosylations. Suzuki couplings followed by arylations, X-ray absorption on rhodium-grafted hydrotalcite catalyst for heterogeneous 1,4-addition reaction of organoboron reagents to electron deficient olefins. It is used in Preparation of combretastatin analogs as potential antitumor agents and human immunodeficiency virus (HIV) protease inhibitors with antiviral activities against drug-resistant viruses

Notes

Store in cool dry conditions. Incompatible with oxidizing agents.

Literature References

Barbara J. B. Johnson. Synthesis of a nitrobenzeneboronic acid-substituted polyacrylamide and its use in purifying isoaccepting transfer ribonucleic acids. Biochemistry. 1981, 20 (21),6103-6108 .

Alan Nadin .; José M. Sánchez López.; Andrew P. Owens.; Dean M. Howells.; Adam C. Talbot.; Timothy Harrison. New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones:? Pd-Catalyzed Cross-Coupling of Imidoyl Chlorides with Organoboronic Acids.J. Org. Chem. 2003, 68 (7),2844-2852 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2931.90
TSCA
No

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