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1074-86-8 - Indole-4-carboxaldehyde, 97% - 4-Formylindole - H28019 - Alfa Aesar

H28019 Indole-4-carboxaldehyde, 97%

CAS Number
1074-86-8
Synonyms
4-Formylindole

Size Price ($) Quantity Availability
250mg 93.80
1g 241.00
5g 749.00
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Indole-4-carboxaldehyde, 97%

MDL
MFCD01632221

Chemical Properties

Formula
C9H7NO
Formula Weight
145.16
Melting point
143-144°
Sensitivity
Air Sensitive
Solubility
Soluble in ethanol and acetone. Insoluble in water.

Applications

4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.

Notes

Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Antoine, M.; et al. Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. J. Enzyme Inhib. Med. Chem. 2008, 23 686.

Eric Fillion; and Aaron M Dumas. Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular friedel-crafts acylation of 4-substituted indoles. Journal of Organic Chemistry. 2008, 73(7), 2920-2923 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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