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4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.
Antoine, M.; et al. Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. J. Enzyme Inhib. Med. Chem. 2008, 23 686.
Eric Fillion; and Aaron M Dumas. Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular friedel-crafts acylation of 4-substituted indoles. Journal of Organic Chemistry. 2008, 73(7), 2920-2923 .
Hazard Statements: H302-H317-H319
Harmful if swallowed. May cause an allergic skin reaction. Causes serious eye irritation.
Precautionary Statements: P261-P264b-P270-P272-P280-P301+P312-P302+P352-P305+P351+P338-P330-P333+P313-P337+P313-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant