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H28019 Indole-4-carboxaldehyde, 97%

CAS Number
1074-86-8
Synonyms
4-Formylindole

Stock No. Size Price ($) Quantity Availability
H28019-MD 250mg 87.80
H28019-03 1g 225.00
H28019-06 5g 698.00
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Indole-4-carboxaldehyde, 97%

MDL
MFCD01632221

Chemical Properties

Formula
C9H7NO
Formula Weight
145.16
Melting point
143-144°
Storage & Sensitivity
Air Sensitive. Store under Argon. Ambient temperatures.
Solubility
Soluble in ethanol and acetone. Insoluble in water.

Applications

4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.

Notes

Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Antoine, M.; et al. Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. J. Enzyme Inhib. Med. Chem. 2008, 23 686.

Eric Fillion; and Aaron M Dumas. Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular friedel-crafts acylation of 4-substituted indoles. Journal of Organic Chemistry. 2008, 73(7), 2920-2923 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317-H319

Harmful if swallowed. May cause an allergic skin reaction. Causes serious eye irritation.

Precautionary Statements: P261-P264b-P270-P272-P280-P301+P312-P302+P352-P305+P351+P338-P330-P333+P313-P337+P313-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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