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87120-72-7 - 4-Amino-1-Boc-piperidine, 97% - 1-Boc-4-piperidinamine - tert-Butyl 4-aminopiperidine-1-carboxylate - H30779 - Alfa Aesar

H30779 4-Amino-1-Boc-piperidine, 97%

CAS Number
87120-72-7
Synonyms
1-Boc-4-piperidinamine
tert-Butyl 4-aminopiperidine-1-carboxylate

Size Price ($) Quantity Availability
1g 48.64
5g 150.75
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4-Amino-1-Boc-piperidine, 97%

MDL
MFCD01076201

Chemical Properties

Formula
C10H20N2O2
Formula Weight
200.28
Melting point
44-48°
Sensitivity
Air Sensitive
Solubility
Insoluble in water.

Applications

4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

Notes

Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Calum Macleod; Blanca I Martinez-Teipel; William M Barker; Roland E Dolle. Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin. Journal of Combinatorial Chemistry,2006, 8(1), 132-140.

Demont, E. et al. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J. Med. Chem,2015, 58 (14), 5649-5673.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.39
TSCA
No

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