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5334-39-4 - 3-Methyl-4-nitro-1H-pyrazole, 97% - H30860 - Alfa Aesar

H30860 3-Methyl-4-nitro-1H-pyrazole, 97%

CAS Number
5334-39-4
Synonyms

Size Price ($) Quantity Availability
5g 73.13
25g 243.08
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3-Methyl-4-nitro-1H-pyrazole, 97%

MDL
MFCD00037864

Chemical Properties

Formula
C4H5N3O2
Formula Weight
127.10
Melting point
131-134°
Boiling Point
325°
Solubility
Slightly soluble in water.

Applications

3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Estrada, A.A., et. al. Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors. J. Med. Chem,2014, 57(3), 921-936.

K Chang, MR Grimmett; DD Ward; and RT Weavers. The Nitration of Brominated Pyrazoles in Aqueous Sulfuric Acid. Australian Journal of Chemistry,1979, 32 (8), 1727 - 1734.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.19
TSCA
No
RTECS
UQ7435000

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