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H30860 3-Methyl-4-nitro-1H-pyrazole, 97%

CAS Number
5334-39-4
Synonyms

Stock No. Size Price ($) Quantity Availability
H30860-06 5g 68.00
H30860-14 25g 225.00
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3-Methyl-4-nitro-1H-pyrazole, 97%

MDL
MFCD00037864

Chemical Properties

Formula
C4H5N3O2
Formula Weight
127.10
Melting point
131-134°
Boiling Point
325°
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in water.

Applications

3-Methyl-4-nitropyrazole is a reactant used in the preparation of aminopyrazole derivatives as potent, selective and brain penetrant Leucine-rich repeat kinase 2(LRRK2) small molecule inhibitors.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Estrada, A.A., et. al. Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors. J. Med. Chem,2014, 57(3), 921-936.

K Chang, MR Grimmett; DD Ward; and RT Weavers. The Nitration of Brominated Pyrazoles in Aqueous Sulfuric Acid. Australian Journal of Chemistry,1979, 32 (8), 1727 - 1734.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.19
TSCA
No
RTECS
UQ7435000

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