Novel axially chiral Rh N-heterocyclic carbene complexes were prepared from axially dissymmetric 1,1?-binaphthalenyl-2,2?-diamine and applied in the Rh-catalyzed enantioselective hydrosilylation of methyl ketones. The enantioselective direct aldol reaction, organocatalyzed by recoverable BINAM- prolinamide derivatives can be highly accelerated by a catalytic amount of a carboxylic acid without a detrimental of the obtained enantioselectivities.
Wei-Liang Duan,; Min Shi,; Guo-Bin Rong. Synthesis of novel axially chiral Rh-NHC complexes derived from BINAM and application in the enantioselective hydrosilylation of methyl ketones Chem. Commun. 2003, (23), 2916-2917.
Gabriela Guillena,; María del Carmen Hita,; Carmen Nájera. High acceleration of the direct aldol reaction cocatalyzed by BINAM-prolinamides and benzoic acid in aqueous media. Tetrahedron: Asymmetry 2006, 17(10), 1493-1497.
Hazard Statements: H302-H318
Harmful if swallowed. Causes serious eye damage.
Precautionary Statements: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a
Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations.