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H31520 (Trifluoromethyl)trimethylsilane, 0.5M soln. in THF

CAS Number

Stock No. Size Price ($) Quantity Availability
H31520-AA 5ml 24.80
H31520-AC 25ml 79.60
H31520-AE 100ml 227.00
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(Trifluoromethyl)trimethylsilane, 0.5M soln. in THF


Chemical Properties

Formula Weight
Boiling Point
Flash Point
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Hydrolyzes in water.


A reagent used in nucleophilic addition of the trifluoromethyl group to aldehydes and ketones.


Moisture Sensitive. Store away from oxidizing agents, water/ moisture.

Literature References

G K Surya Prakash; Chiradeep Panja; Habiba Vaghoo; Vijayalakshmi Surampudi; Roman Kultyshev; Mihirbaran Mandal; Golam Rasul; Thomas Mathew; George A Olah. Facile synthesis of TMS-protected trifluoromethylated alcohols using trifluoromethyltrimethylsilane (TMSCF3) and various nucleophilic catalysts in DMF. Journal of Organic Chemistry. 2006, 71 (18), 6806-6813.

Rajendra P. Singh; Ganfeng Cao; Robert L. Kirchmeier and Jean'ne M. Shreeve. Cesium Fluoride Catalyzed Trifluoromethylation of Esters, Aldehydes, and Ketones with (Trifluoromethyl)trimethylsilane. J. Org. Chem. 1999, 64 (8), 2873-2876.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302-H319-H335-H336-H351

Highly flammable liquid and vapour. Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation. May cause drowsiness or dizziness. Suspected of causing cancer.

Precautionary Statements: P201-P202-P210-P233-P235-P240-P241-P242-P243-P264b-P270-P271-P280i-P281-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P330-P370+P378q-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


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