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1H-1,2,4-Triazole-1-acetic acid is used to produce (1-hydroxy-1-phosphono-2-[1,2,4]triazol-1-yl-ethyl)-phosphonic acid at the temperature of 100 - 110°C. It will need reagent H3PO4, PCl3 and solvent chlorobenzene
Ioannis N. Houpis.; Renmao Liu.; Yanfei Wu.; Yukuan Yuan.; Youchu Wang.; Ulrike Nettekoven. Regioselective Cross-Coupling Reactions of Boronic Acids with Dihalo Heterocycles. J. Org. Chem. 2010, 75, (20), 6965-6968.
De-Gang Ding.; Li-Xia Xie.; Yao-Ting Fan.; Hong-Wei Hou.; Yan Xu. Syntheses, crystal structures and fluorescent properties of Cd(II), Hg(II) and Ag(I) coordination polymers constructed from 1H-1,2,4-triazole-1-acetic acid. Journal of Solid State Chemistry. 2009, 182, (6), 1443-1449.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.