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4-(Trifluoromethylsulfonyl)phenylacetic acid, is used as a primary and secondary intermediate.
A Aramini.; MR Sablone.; G Bianchini.; A Amore.;M Fanì. Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI. Tetrahedron..200965 (10), 2015-2021.
E Valeur.; M Bradley. Amide bond formation: beyond the myth of coupling reagents. Chemical Society Reviews.200938 (1), 606-631.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.