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H32389 5-Fluoro-2-methoxybenzoic acid, 97%

CAS Number
394-04-7
Synonyms

Stock No. Size Price ($) Quantity Availability
H32389-03 1g 66.10
H32389-06 5g 274.00
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5-Fluoro-2-methoxybenzoic acid, 97%

MDL
MFCD00671765

Chemical Properties

Formula
C8H7FO3
Formula Weight
170.14
Melting point
86-90°C
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

5-Fluoro-3-hydroxy-2-methylbenzoic acid 1 was synthesized from 5-fluoro-2-methylbenzoic acid by nitration, reduction, diazotization and hydrolysis. Another methylcarbamoyl-substituted benzylamine 12 was synthesized from 5-fluoro-2-methylbenzoic acid via the sequential bromination,azido replacement and the reduction.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Eiji Takashiro,; Ichiro Hayakawa,; Tamayo Nitta,; Atsushi Kasuya,; Shuichi Miyamoto,; Yuji Ozawa,; Ryuichi Yagi,; Ikue Yamamoto,; Takahiro Shibayama,; Akihiko Nakagawa,; Yuichiro Yabe. Structure-activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P1 site. Bioorganic & Medicinal Chemistry. 1999, 7(9),2063-2072.

Xing Fana,; Feng-Hua Zhanga,; Rasha I. Al-Safi,; Li-Fan Zenga,; Yumna Shabaik,; Bikash Debnath,; Tino W. Sanchez,; Srinivas Odde,; Nouri Neamati,; Ya-Qiu Long. Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: A scaffold hopping approach using salicylate and catechol groups. Bioorganic & Medicinal Chemistry. 2011, 19(16), 4935-4952.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Harmonized Tariff Code
2918.99
TSCA
No

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