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Used in suzuki-miyaura coupling reaction. The palladium-catalyzed coupling reaction of arylboronicacids with ethyl glyoxylate provides a straightforward method for the synthesis of mandelic esters. Mandelic esters were isolated in good-to-excellent yields with a variety of neutral, slightly electron-rich, and slightly electron-poor substituents.
Zhongyu Duan,; Sadananda Ranjit,; Xiaogang Liu. One-Pot Synthesis of Amine-Substituted Aryl Sulfides and Benzo[b]thiophene Derivatives. Org. Lett., 2010, 12 (10), 2430-2433.
Irene Notar Francesco,; Alain Wagner,; Françoise Colobert. Suzuki-Miyaura Coupling Reaction of Boronic Acids and Ethyl Glyoxylate: Synthetic Access to Mandelate Derivatives. European Journal of Organic Chemistry. 2008, 34 issue , 5692-5695.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.