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4-Fluoro-3-(trifluoromethyl)aniline is used in the synthesis of trifluoromethylated poly(phenylene oxide). It is used in the preparation of 2-[3-(4-fluoro-3-trifluoromethyl-phenyl)-ureido]-2-methyl-propionic acid methyl ester by reacting with 2-isocyanato-2-methyl-propionic acid methyl ester. It is also used as a chemical intermediate in the synthesis of agrochemicals, pharmaceuticals and dyes.
Abbott, P. A.; Bonnert, R. V.; Caffrey, M. V.; Cage, P. A.; Cooke, A. J.; Donald, D. K.; Furber, M.; Hill, S.; Withnall, J. Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5-a]quinoline, [1,2,3]triazolo[1,5-a]quinazoline, [1,2,3]triazolo[1,5-a]quinoxaline and [1,2,3]triazolo[5,1-c]benzotriazine derivatives. Tetrahedron 2002, 58 (16), 3185-3198.
Hazard Statements: H302-H311-H315-H319-H332
Harmful if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P361-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant