2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification.
QIAO Juan,; HUANG Rongqing,; XIAO Bingkun,; LUO Chuanhuan,; ZHANG Hongyi,; XIE Huijun. Synthesis of 2-Amino-5-fluorophenol-N, N, O-triacetic Acid Trimethyl Ester. Science Technology and Engineering. 2004,
Raimund Peter,; Ronald Boecker,; Philippe H. Beaune,; Masahiko Iwasaki,; F. Peter Guengerich,; Chung S. Yang. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chem. Res. Toxicol. 1990, 3(6), 566-573.
Hazard Statements: H302-H312-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338-P312a
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER/doctor if you feel unwell.