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H33003 2-Methyl-6-(trifluoromethyl)nicotinic acid, 97%

CAS Number
2-Methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid

Stock No. Size Price ($) Quantity Availability
H33003-03 1g 44.20
H33003-09 10g 372.00
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2-Methyl-6-(trifluoromethyl)nicotinic acid, 97%


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Ambient temperatures.
Slightly soluble in water (4.7 g/L at 25°C).


2-Methyl-6-(trifluoromethyl)nicotinic acid is used as a pharmaceutical intermediate.


Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

Kirk D. Robarge.; Shirley A. Brunton.; Georgette M. Castanedo.; Yong Cuia, Michael S. Dina.; Richard Goldsmith.; Stephen E. Gould.; Oivin Guichert.; Janet L. Gunzner.; Jason Halladay.; Wei Jia.; Cyrus Khojasteh.; Michael F.T. Koehlera, Karen Kotkowc, Hank Laa, Rebecca L. LaLondea, Kevin Lau.; Leslie Lee.; Derek Marshall.; James C. Marsters Jr.; Lesley J. Murray.; Changgeng Qian.; Lee L. Rubin.; Laurent Salphati.; Mark S. Stanley.; John H.A. Stibbard.; Daniel P. Sutherlin.; Savita Ubhayaker.; Shumei Wang.; Susan Wong.; Minli Xie. GDC-0449—A potent inhibitor of the hedgehog pathway. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (19), 5576-5581.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

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