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2-Methyl-6-(trifluoromethyl)nicotinic acid is used as a pharmaceutical intermediate.
Kirk D. Robarge.; Shirley A. Brunton.; Georgette M. Castanedo.; Yong Cuia, Michael S. Dina.; Richard Goldsmith.; Stephen E. Gould.; Oivin Guichert.; Janet L. Gunzner.; Jason Halladay.; Wei Jia.; Cyrus Khojasteh.; Michael F.T. Koehlera, Karen Kotkowc, Hank Laa, Rebecca L. LaLondea, Kevin Lau.; Leslie Lee.; Derek Marshall.; James C. Marsters Jr.; Lesley J. Murray.; Changgeng Qian.; Lee L. Rubin.; Laurent Salphati.; Mark S. Stanley.; John H.A. Stibbard.; Daniel P. Sutherlin.; Savita Ubhayaker.; Shumei Wang.; Susan Wong.; Minli Xie. GDC-0449A potent inhibitor of the hedgehog pathway. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (19), 5576-5581.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant