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H33442 2,5-Dichloro-4-(trifluoromethyl)pyridine, 97%

CAS Number

Stock No. Size Price ($) Quantity Availability
H33442-MD 250mg 61.10
H33442-03 1g 169.00
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2,5-Dichloro-4-(trifluoromethyl)pyridine, 97%


Chemical Properties

Formula Weight
Boiling Point
Storage & Sensitivity
Ambient temperatures.


2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)pyridine were each converted into the three possible carboxylic acids 2, 4, 6,8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic “toolbox methods”: transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, aluminum. Protection under nitrogen and lower temperature is recommended(below 4 deg C).

Literature References

Florence Mongin,; Antonio Tognini,; Fabrice Cottet,; Manfred Schlosses. Halogen shuffling in pyridines: Site selective electrophilic substitutions of 2-chloro-6-(trifluoromethyl)pyridine. Tetrahedron Letters. 1998, 39(13), 1749-1752.

Fabrice Cottet,; Marc Marull,; Olivier Lefebvre,; Manfred Schlosser. Recommendable Routes to Trifluoromethyl-Substituted Pyridine- and Quinolinecarboxylic Acids. European Journal of Organic Chemistry. 2003, 81559-1568,.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • H32840

    6-Hydroxy-1-tetralone, 97%
  • 36292

    Acetic anhydride, ACS, 97+%
  • H59498

    2-Chloro-N-(2,6-dichlorophenyl)benzamide, 97%
  • 11235

    Praseodymium(III, IV) oxide, REacton®, 99.99% (REO)
  • 47036

    Viscosity standard, Specpure®, nominally 10cSt @ 40° and 2.7cSt @ 100°

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