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H33520 3-Methyl-5-(trifluoromethyl)benzyl bromide, 97%

CAS Number

Stock No. Size Price ($) Quantity Availability
H33520-MD 250mg 46.90
H33520-03 1g 155.00
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3-Methyl-5-(trifluoromethyl)benzyl bromide, 97%


Chemical Properties

Formula Weight
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.


A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve potency was found. 3,5-Bis(trifluoromethyl)benzyl bromide has been used as derivatization reagent in detection of uracil in DNA by GC and negative chemical ionization mass spectrometry.


Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, moisture, water.

Literature References

Ho-Jane Shue,; Xiao Chen,; John H. Schwerdt,; Sunil Paliwal,; David J. Blythin,; Lng Lin,; Dalina Cheng Wang,; Gregory A. Reichard,; Hongwu Wang,; John J. Piwinski,; Ruth A. Duffy,; Jean E. Lachowicz,; Vicki L. Coffin,; Amin A. Nomeir,; Cynthia A. Morgan.Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions. Bioorganic & Medicinal Chemistry Letters. 2006, 16(14) ,1065-1069.

Igor Kazmierski,; Mylène Bastienn,; Corinne Gosmini,; Jean-Marc Paris,; Jacques Périchon. Convenient Processes for the Synthesis of Aromatic Ketones from Aryl Bromides and Carboxylic Anhydrides Using a Cobalt Catalysis. J. Org. Chem. 2004, 69(3),936-942.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


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