This coupling agent specifically reacts with alkyne functions to form the corresponding 1,2,3-triazole via a copper-free 1,3-dipolar cycloaddition.
Jef Ryken,; Jiaqi Li,; Tim Steylaerts,; Rita Vos,; Josine Loo,; Karolien Jans,; Willem Van Roy,; Tim Stakenborg,; Pol Van Dorpe,; Jeroen Lammertyn,; Liesbet Lagae. Biosensing with SiO2-covered SPR substrates in a commercial SPR-tool . Sensors and Actuators B: Chemical. 2014, 200 167-172.
Jonathan Sabaté del Río,; Tim Steylaerts,; Olivier Y.F. Henry,; Peter Bienstman,; Tim Stakenborg,; Wim Van Roy,; Ciara K. OSullivan. Real-time and label-free ring-resonator monitoring of solid-phase recombinase polymerase amplification. Biosensors and Bioelectronics. 2015, 73 130-137.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.