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1214340-18-7 - 2-Chloro-4-(trifluoromethyl)anisole, 97% - 2-Chloro-1-methoxy-4-(trifluoromethyl)benzene - 3-Chloro-4-methoxybenzotrifluoride - H33554 - Alfa Aesar

H33554 2-Chloro-4-(trifluoromethyl)anisole, 97%

CAS Number
1214340-18-7
Synonyms
2-Chloro-1-methoxy-4-(trifluoromethyl)benzene
3-Chloro-4-methoxybenzotrifluoride

Size Price ($) Quantity Availability
250mg 68.70
1g 84.62
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2-Chloro-4-(trifluoromethyl)anisole, 97%

MDL
MFCD13185462

Chemical Properties

Formula
C8H6ClF3O
Formula Weight
210.58
Refractive Index
1.4755
Solubility
Sparingly soluble in water.(0.26 g/L) (25°C),

Applications

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Notes

Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.

Literature References

C. Elisabet Tranberg.; Andrea Zickgraf.; Brian N. Giunta.; Henning Luetjens.; Heidi Figler.; Lauren J. Murphree.; Ruediger Falke.; Holger Fleischer.; ? Joel Linden.; Peter J. Scammells.; Ray. A. Olsson. 2-Amino-3-aroyl-4,5-alkylthiophenes:? Agonist Allosteric Enhancers at Human A1 Adenosine Receptors.J. Med. Chem. 2002, 45 (2),382-389 .

Robert H. Dodd.; Catherine Ouannes.; Malka Robert-Gero.; Pierre Potier. Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-.beta.-carbolines.J. Med. Chem. 1989, 32 (6),1272-1276 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2909.30
TSCA
No

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