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H33603 (R)-(-)-4-Fluorostyrene oxide, 98+%, ee 98+%

CAS Number
134356-73-3
Synonyms
(R)-(-)-2-(4-Fluorophenyl)oxirane

Stock No. Size Price ($) Quantity Availability
H33603-03 1g 104.00
H33603-06 5g 427.00
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(R)-(-)-4-Fluorostyrene oxide, 98+%, ee 98+%

MDL
MFCD03788740

Chemical Properties

Formula
C8H7FO
Formula Weight
138.14
Boiling Point
92/14mm
Density
1.17
Refractive Index
1.5087
Storage & Sensitivity
Ambient temperatures.
Solubility
Sparingly soluble in water.(0.26 g/L) (25°C),

Applications

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Notes

Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.

Literature References

C. Elisabet Tranberg.; Andrea Zickgraf.; Brian N. Giunta.; Henning Luetjens.; Heidi Figler.; Lauren J. Murphree.; Ruediger Falke.; Holger Fleischer.; ? Joel Linden.; Peter J. Scammells.; Ray. A. Olsson. 2-Amino-3-aroyl-4,5-alkylthiophenes:? Agonist Allosteric Enhancers at Human A1 Adenosine Receptors.J. Med. Chem. 2002, 45 (2),382-389 .

Robert H. Dodd.; Catherine Ouannes.; Malka Robert-Gero.; Pierre Potier. Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-.beta.-carbolines.J. Med. Chem. 1989, 32 (6),1272-1276 .

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H302-H312-H315-H319-H332-H335-H351

Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation. Suspected of causing cancer.

Precautionary Statements: P201-P202-P210-P233-P235-P240-P241-P242-P243-P261-P264b-P270-P271-P280i-P281-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P337+P313-P363-P37

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Wash contaminated clothing before reuse.

Other References

Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2910.90
TSCA
No

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