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H33746 (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate, 98%

CAS Number

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(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate, 98%


Chemical Properties

Formula Weight
Melting point
ca 160° dec.
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Air Sensitive. Store under Nitrogen.
Soluble in DMF 1mmol in 2mL.


(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.


Air and moisture sensitive. Store away from air, heat, water/ moisture and oxidizing agents.

Literature References

Ayman El-Faham; Ramon Subirós Funosas; Rafel Prohens; Fernando Albericio. COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents. Chemistry: A European Journal. 2009, 15 (37), 9404-9416.

Ramon Subiros-Funosas; Gerardo A. Acosta; Ayman El-Faham; Fernando Albericio. Microwave irradiation and COMU: a potent combination for solid-phase peptide synthesis.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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