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(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.
Ayman El-Faham; Ramon Subirós Funosas; Rafel Prohens; Fernando Albericio. COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents. Chemistry: A European Journal. 2009, 15 (37), 9404-9416.
Ramon Subiros-Funosas; Gerardo A. Acosta; Ayman El-Faham; Fernando Albericio. Microwave irradiation and COMU: a potent combination for solid-phase peptide synthesis. 2012, 50 (45), 6200-6202.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.